April 21, 2022
- Toronto Maple Leafs @ Tampa Bay Lightning
- Chicago Blackhawks @ Los Angeles Kings
- New York Rangers @ New York Islanders
- St. Louis Blues @ San Jose Sharks
- Winnipeg Jets @ Carolina Hurricanes
- Dallas Stars @ Calgary Flames
- Detroit Red Wings @ Florida Panthers
- Vancouver Canucks @ Minnesota Wild
- Philadelphia Flyers @ Montréal Canadiens
- Buffalo Sabres @ New Jersey Devils
- Boston Bruins @ Pittsburgh Penguins
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